LCMS - Psychotropic Medication 3 Antidepressants TDM LC-MS

Psychotropic Medication 3 (Antidepressants) Reagent set

SKU: 4090 KIT P PS3

The advantages of the Psychotropic Medication 3 Antidepressants Reagent kit for LC-MS/MS:

Balanced panel for cost reducing and optimal chromatography with optimized mobile phases
Simple and improved column life sample preparation without SPE or LLE
Internal standard for all components

Components

Citalopram
Norcitalopram
Fluoxetine
Norfluoxetine
Fluvoxamine
Mirtazapine
Normirtazapine
Paroxetine
Sertraline
Norsertraline
Venlafaxine
Norvenlafaxine

At a glance

Matrix: Serum
Technique: LC-MS/MS
Interne Standaard: Citalopram-D6, Norcitalopram-D3, Fluoxetine-D5, Fluvoxamine-D3, Mirtazapine-D3, Normirtazapine-D6, Paroxetine-D6, Sertraline-D3, Venlafaxine-D6, Norvenlafaxine-D6, Norsertraline-13C6

Intended Use

The Diagnotix Psychotropic Medication 3 LC-MS Reagent Kit is designed to determine the concentration of one or more of the listed Antidepressants analytes and metabolites in serum or plasma as a basis for further diagnostics.

Technical Benefits

Balanced panel: The most abundant compounds and their common metabolites are chosen to ensure that the panel is not too large, but still meets the challenges of routine use. The larger the panel, the more costs are involved to include all analytes and their isotopes, but also more trade-offs must be made for chromatographic optimization.
Column and LC-MS friendly: Mobile phases are optimized for these compounds and for increase column life time. Also, only a small injection volume is required for most systems.
Cost-effective and fast automatable sample preparation: No more SPE or LLE is needed.

Why moving over from HPLC-UV to LC-MS?

By switching to LC-MS, you immediately save on the use of SPE or LLE, longer sample preparation and therefore labor costs. In addition, the runtime of your method is probably shorten and you do not have to worry about interfering other drugs, as long as they do not share the same mass transitions.And because baseline separations are no longer necessary and the mobile phases do not have to contain high concentration buffers, you benefit from a much longer column life.

Especially interesting for laboratories that:

I. Have regular (large) batches of Antidepressants patient samples and have a reliable automatable workflow.

II. Already have an LC-MS system, but still perform TDM or Antidepressants analyses on HPLC-UV machines. Eliminating the use of your HPLC-UV system will immediately improve operational efficiency and reduce overall maintenance costs.

Contact Us for More Information

Interested in learning more about our Psychotropic Medication 3 solution for Antidepressants? Contact us via the contact form below. We looking forward to hear from you!

Included in kit (300 assays)

4091 CAL P PS3, Calibrator Set (Calibrator 1 – 6), 6 x 2 x 500 μl
4099 P PS3, Internal Standard, 6 x 2.5 ml
4100 P PS3, Deproteinization Solution, 3 x 40 ml
4104 P PS3, Mobile Phase I, 2 x 250 ml
4105 P PS3, Mobile Phase II, 2 x 250 ml
4106 P PS3, Autosampler washing solution, 1 x 500 ml

Therapeutic Drug Monitoring (TDM) is based on the assumption that there is a relationship between the blood concentration and clinical effect (therapeutic improvement and adverse effects). It also assumes there is a concentration range of the drug which is characterized by maximal effectiveness and maximal safety, the “therapeutic window”.